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A new term has appeared in the vocabulary of modern physicians, pharmacists, and health care administrators: "evidence-based medicine (evidence-based medicine). The philosophical meaning of this concept can be explained by a dualistic thesis that has long been debated in medical circles: Is medicine a science or an art? Let us compare the European and American models of physician practice as an example. The American model is considered to be formalized, within a rigid framework of standards of care. The advantage and weakness of this model is that it is rigidly programmed, which, on the one hand, reduces the number of medical errors (it is enough to follow the standards precisely), but, on the other hand, limits the choice of therapeutic tactics. Thus, the American model of medicine resembles an assembly line - highly productive, but clumsy. The European model is more like art, in that it provides the physician with room for creativity. This model is more flexible, but less productive and less error-prone than the American model. Recently, however, the difference between the two models of medicine has been leveled out by the practical application of evidence-based medicine. Evidence-based medicine is a branch of evidence-based medicine that seeks, compares, summarizes, and disseminates widely the evidence obtained for the benefit of patients (Evidence Based Medicine Working Group, 1993). Evidence-based medicine is a new approach, direction, or technology for collecting, analyzing, synthesizing, and interpreting scientific information. Evidence-based medicine involves the conscientious, understandable, and common sense use of the best current advances to treat each patient (Sackett D.L. et al., 1996). The main goal of introducing evidence-based medicine into health care practice is to optimize the quality of care in terms of safety, effectiveness, cost, and other relevant factors. No practitioner has sufficient experience to be able to freely navigate all the variety of clinical situations. One can rely on expert opinions, authoritative manuals and reference books, but this is not always reliable because of the so-called lag effect - promising therapeutic methods are introduced into practice a considerable time after evidence of their effectiveness (Antman E.T. et al., 1992). On the other hand, information in textbooks, manuals, and reference books is often outdated before they are published, and the age of the treating experienced clinician is negatively correlated with treatment efficacy (Sackett D.L. et al., 1991). These conclusions were obtained using the main statistical tool of evidence-based medicine, metaanalysis. Consequently, there is a need to summarize biomedical knowledge and widely inform the medical community about the results of the latest research. The potential applications of the principles of evidence-based medicine in health care practice are considerable. First of all, their application allows the use of objective criteria for all aspects of pharmacotherapy. The principles of evidence-based medicine provide an opportunity to optimize the influence on decision-making of such largely subjective factors as intuition and qualifications of the physician, opinions of authoritative experts, and recommendations of popular manuals and reference books, taking into account the latest and reliable information. Thus, evidence-based medicine involves combining the individual clinical experience of a physician with the best available independent clinical evidence from systematic studies. At the same time, the principles of evidence-based medicine allow the development of the most effective, safe and cost-effective modern therapeutic strategies that can be implemented at the state, regional, population, subpopulation and individual levels, contributing to the choice of the optimal option in each specific clinical case. Let us focus on some aspects of the practical application of the principles of evidence-based medicine. First of all, they are applicable to improve the quality of medical care: it is the development of clinical guidelines for practitioners and the implementation of standardization systems in health care. Meta-analysis is a statistical method that allows combining the results of independent studies. It is most often used to assess the clinical effectiveness of therapeutic interventions by combining the results of two or more randomized controlled trials. The information value of meta-analysis depends on the quality of the systematic review on which it is based. Qualitative meta-analysis involves reviewing all studies on the relevant problem, assessing heterogeneity, and determining the informative value of the main results through sensitivity analysis.